张彪，博士，2021年毕业于上海交通大学电子信息与电气工程学院。研究方向为生物信息学。当前主持一项浙江省自然科学基金，参入3项国家自然科学基金项目。开发基于冷冻电子显微镜的蛋白质结构拟合、重构和优化的算法及服务器。近五年，在包括 Nature Methods，Nature Communications、Journal of Molecular Biology、Briefings in bioinformatics，Journal of Chemical Information and Modeling、The Journal of Physical Chemistry、IEEE/ACM Transactions on Computational Biology and Bioinformatics 等生物信息学与模式识别领域的国际权威期刊上发表相关的学术论文 10 余篇。
发表论文 Journal Articles
- Xi Zhang, Biao Zhang, Peter L Freddolino, Yang Zhang. CR-I-TASSER: Assemble Protein Structures from Cryo-EM Density Maps using Deep Convolutional Neural Networks. Nature Methods (2022): 1-10.
- Sang Ho Park, Alex Ayoub, Young-Tae Lee, Jing Xu, Hanseong Kim, Wei Zheng, Biao Zhang, Liang Sha, Sojin An, Yang Zhang, Michael A Cianfrocco, Min Su, Yali Dou, Uhn- Soo Cho. Cryo-EM structure of the human MLL1 core complex bound to the nucleosome. Nature Communications, 10: 5540 (2019).
- Biao Zhang, Xi Zhang, Robin Pearce, Hong-Bin Shen, and Yang Zhang. A new protocol for atomic-level protein structure modeling and refinement using low-to-medium resolution cryo- EM density maps. Journal of Molecular Biology, 2020, 432(19): 5365-5377. (2020). [Web Server]
- Biao Zhang, Dong Liu, Yang Zhang, Hongbin Shen and Guijun Zhang. Accurate flexible refinement for atomic-level protein structure using cryo-EM density maps and deep learning, Briefings in Bioinformatics, 2022; bbac026, https://doi.org/10.1093/bib/bbac026.
- Biao Zhang, Wenyi Zhang, Robin Pearce, Yang Zhang, and Hong-Bin Shen. Fitting predicted protein atomic structures into a density map using multiobjective optimization of global and local energies. The Journal of Physical Chemistry B, 125.2 (2021): 528-538. [Web Server]
- Minghua Hou, Chunxiang Peng, Xiaogen Zhou, Biao Zhang and Guijun Zhang. Multi contact- based folding method for de novo protein structure prediction, Briefings in Bioinformatics, 2021; bbab463, https://doi.org/10.1093/bib/bbab463.
- Shuo Yin, Biao Zhang, Yang Yang, Yan Huang and Hong-Bin Shen. Clustering enhancement of noisy cryo-electron microscopy single-particle images with a network structural similarity metric. Journal of Chemical Information and Modeling, 2019, 59: 1658-1667.
- Yu-Jiao Yang, Shuai Wang, Biao Zhang and Hong-Bin Shen. Resolution measurement from a single reconstructed cryo-EM density map with multi-scale spectral analysis. Journal of Chemical Information and Modeling 58.6 (2018): 1303-1311.
- Jing Yang, Qi-Yu Jin, Biao Zhang, and Hong-Bin Shen. R2C: Improving ab initio residue contact map prediction using dynamic fusion strategy and Gaussian noise filter. Bioinformatics, 2016, 32: 2435-2443.
发明专利 Patents
- 张彪; 沈红斌 ; 基于能量的原子结构与电子密度图多目标优化拟合预测方法, 2020- 08-07, 中国, CN 202010789510.7 (专利)