Elucidating the structure and function of protein molecules is the crucial step to understanding the mysteries of life. The main focuses of our lab include: 1) protein structure and function prediction; 2) protein structure modeling from cryo-EM data; 3) predicting protein-ligand interaction sites and the spatial posture. Recently, we are also working on designing new proteins with new functions beyond nature proteins. The lab's research results will accelerate human's understanding of how life works, and accelerate the process of target discovery and drug design.

Research Areas
  • Protein structure prediction
  • Quality assessment of protein models
  • Protein functional sites prediction
  • Protein structure modelling from cryo-EM density maps
  • Protein macromolecular structure assembly
  • Deep learning for protein structure refinement and protein design
Lab News
  • The research group participated in 2022 The 3rd Integrative Bioinformatics Conference on “Agriculture, Health and Ecology” Prof. Guijun Zhang served as the secretary of the conference, Dr. Xiaogen Zhou given a special invitation report at the conference, and PhD student Chunxiang Peng given a presentation at the postgraduate forum.
  • PhD student Chunxiang Peng's paper "Structural analogue-based protein structure domain assembly assisted by deep learning" was accepted by Bioinformatics.
  • Researcher Luonan Chen and Researcher Xiaoping Liu from Hangzhou Institute for Advanced Study of UCAS visited the laboratory to guide the work..
  • PhD student Chunxiang Peng won the rolling funding after passing the mid-term examination of excellent doctoral dissertation cultivation of Zhejiang University of Technology, and PhD student Kailong Zhao received the excellent doctoral dissertation grant from Zhejiang University of Technology.