Pathfinder
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Pathfinder predicted the folding pathways of 34 proteins and provides intermediate states (Download) . The following shows the intermediate state, near-native state and native state of 4 proteins. The order from left to right represents the order of protein folding.

Note: Users can observe the structural details of these intermediate states by dragging or scrolling with the mouse.

B1 immunoglobulin-binding domain of streptococcal protein G (PDB ID: 1pgb)

Intermediate 1

Intermediate 2

Near-Native

Native

B1 domain of the protein L from Peptostreptococcus magnus (PDB ID: 1hz5)

Intermediate 1

Intermediate 2

Near-Native

Native

Src-Homology3 (SH3) Domain (PDB ID: 1shg)

Intermediate 1

Intermediate 2

Near-Native

Native

LYSM Domain from E.coli MLTD (PDB ID: 1e0g)

Intermediate 1

Intermediate 2

Near-Native

Native

References

  • Zhaohong Huang, Xinyue Cui, Yuhao Xia, Kailong Zhao and Guijun Zhang. Pathfinder: protein folding pathway prediction based on conformational sampling. Submitted.


Contact us

  • guijunzhanglab@163.com