SAMAffinity is a computational tool for predicting changes in protein–protein binding affinity induced by amino acid mutations, aiming to achieve high-throughput and high-accuracy predictions based solely on protein sequence data. (More about SAMAffinity...)

• 2025/11/05: We developed SAMAffinity for mutation-induced binding affinity changes.

• Zhuang, Jianan and Li, Zonghui and Wang, Suhui and Zheng, Renchao and Zhang, Guijun*. Sequence-aware Prediction of Point Mutation-induced Effects on Protein-Protein Binding Affinity using Deep Learning. bioRxiv, DOI: https://doi.org/10.1101/2025.11.15.688659