DeepSCFold standalone package develops structural similarity and interaction probability prediction models to capture structural complementarity and construct paired-MSAs. It also integrates AlphaFold-Multimer and MULTICOM3 to enhance the accuracy of protein complex structure prediction.


DeepSCFold download:
  • For academic users, please click here to download the DeepSCFold package.
  • If you need DeepSCFold for a commercial use, please contact us (Email: zgj@zjut.edu.cn).

  • Release Note:
  • v1.0 (2025/03/07): original version of DeepSCFold.

  • Databases:
  • PDB70
  • PDB_mmcif
  • PDB_seqres
  • UniRef30
  • uniProt
  • UniRef90
  • Uniclust30
  • ColabFold DB
  • BFD
  • MGnify
  • Metaclust
  • Integrated Microbial Genomes (IMG)
  • STRING
  • pdb_complex
  • pdb_sort90

  • References
  • Minghua Hou, Yuhao Xia, Pengcheng Wang, Zexin lv, Dongliang Hou, Jianyang Zeng and Guijun Zhang. High-accuracy protein complex structure modeling based on sequence-derived structure complementarity. In press.

  • License

    MIT License

    Copyright (c) 2025 Guijun Zhang

    Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions:

    The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software.

    THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.